The research on both chondroitin and MSM is very controversial. Chondroitin, for instance, has very poor absorption due to its high molecular weight. Likewise, research on MSM is not conclusive. In fact, it takes large quantities of MSM daily (2-6 grams) to make a difference and see effects.
Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Although it is produced naturally by the body, the level of hyaluronic acid diminishes with age, contributing to joint discomfort. It is a key component of cartilage, and is important for skin, joint and eye health. Hyaluronic acid has been shown to help maintain strong, healthy cartilage. It may also enhance synovial fluid production and promote normal healing.
Research behind glucosamine is consistent and its benefits effective. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage, and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints and regenerates cartilage.
Pycnogenol is an ingredient that should be included in joint formulas, but is not very common. The body’s inflammatory response is a natural process. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol has been shown help support the body’s defense system by inhibiting over active inflammatory responses associated with the normal aging process.
One product that includes Glucosamine, Hyaluronic Acid and Pycnogenol is Prime™ Joint Support Formula by Isotonix®. The beauty of this product is that not only does it supply all the ingredients that have been proven to work best for joint support, but it does so in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream.